Are the motors ready to move:

• Do you have holding torque on the motors?
• Are they powered OK?
• Is there a motor/driver enable signal? Can you jump it?
• Can you command the motors to move using other means? Like configuration software?

Are the step and direction signals getting to the motor?

• Verify the pinout configuration.
• Is there an OUTPUT ENABLE?  All the CNC4PC breakout boards have hardware enable and all the multifunction have also a Safety Charge Pump, which is a watchdog to enable the outputs only when the control software is in control.  All these boards have an LED that activates.  Usually there is a Step by Step instructions on setting up the board and on the last step we validate that the breakout board is indeed activated with the SCHP.
• Trace the signals.  Keep in mind that the direction signal will change status when you command the motor to move in a different direction than what it was moving before.  It may be hard to test the step pin as it is a fast pulse stream, but if you invert the active high/low of the stop pin in the configuration, you will see it changing states.
• Check for action on the step and direction pins on the control software, motion controller plugin, LEDs of the breakout board, and with a multimeter on the terminals of the breakout board, if possible pins of the motion controller, and terminals of the drivers.
• Verify the microstepping and/or number of pulses you are sending, or step per pulse.  Newer drivers can have a crazy high resolution and require a lot of steps, or on the contrary, it may be possible that you are sending a crazy high fast pulse stream that the driver is not able to react to.